Depalgos 20 mg + 325 mg

-14%

Depalgos 20 mg + 325 mg

120.00$

Pharmacotherapeutic group: opioid analgesics in combination with non-opioid analgesics, ATC code: N02AJ17
DEPALGOS is the combination of 2 active substances, paracetamol and oxycodone.
Oxycodone is a complete opioid agonist …

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Description

Buy Depalgos .

Depalgos – Coated Tablets is a drug based on the active ingredientOxicodone + Paracetamol, belonging to the category of opioid analgesics and specifically Opioids in combination with non-opioid analgesics . It is marketed in Italy by the companyL. Molteni & C. dei F.lli Alitti Company of Exercise SpA.

Depalgos – Coated Tablets can be prescribed with RNR Recipe – medicines subject to medical prescription to be renewed from time to time .


Packs

Depalgos 10 mg + 325 mg 28 coated tablets
Depalgos 20 mg + 325 mg 28 coated tablets
Depalgos 5 mg + 325 mg 28 coated tablets

Commercial Prescribing Information

Holder: L. Molteni & C. dei F.lli Alitti Company of Exercise SpA
Dealer: L. Molteni & C. dei F.lli Alitti Company of Exercise SpA
Recipe: RNR – medicines subject to medical prescription to be renewed from time to time
Class: A
Active ingredient:Oxicodone + Paracetamol
Therapeutic group: Opioid analgesics
Pharmaceutical form: coated tablets

Indications

  • Treatment of pain of moderate to severe degenerative origin in the course of musculo-osteoarticular diseases not controlled by (NSAID) / paracetamol used alone.
  • Treatment of moderate to severe cancer pain.

Dosage.

DEPALGOS is only indicated in patients over 18 years of age.
The dosage depends on the intensity of the pain and on any previous analgesic treatments.
In any case, 4000 mg of acetaminophen per day or 80 mg of oxycodone per day should never be exceeded .
treatment of pain of moderate to severe degenerative origin in course of musculo-osteoarticular diseases not controlled by NSAIDs / paracetamol used alone
Treatment should be started with one “5 mg + 325 mg” tablet every 6-8 hours.
Continue therapy until pain is adequately controlled.
If necessary, the dose can be increased according to the patient’s response using the dosages of DEPALGOS available, in 3-4 daily administrations. Generally, the period of about one month is sufficient to achieve adequate pain control.
Moderate to severe cancer pain
Initial dosage
  • Patients receiving opioids for the first time or with pain not controlled by other weak opioids:
The daily dose is represented by one “5 mg + 325 mg” tablet every 6 hours.
  • Patients previously treated with strong opiates:
The starting daily dose should be based on the previously taken daily opioid dose. For the calculation of the initial daily dose it should be considered that the equi-analgesia ratio between oral oxycodone and oral morphine is approximately 1 to 2 (i.e. 10 mg of oxycodone corresponds to 20 mg of morphine).
The total dose obtained is divided and administered every 6 hours, using the most appropriate tablets among the available dosages (“5 mg + 325 mg“, “10 mg + 325 mg“ and “20 mg + 325 mg“).
Adjustment of the dosage
If the prescribed doses prove insufficient, the dosage can be progressively increased using the available dosages “5 mg + 325 mg”, “10 mg + 325 mg” and “20 mg + 325 mg” until pain control is achieved and taking present the maximum daily dosages reported above.
If repeated or prolonged treatment is necessary, it is advisable that this is interspersed with therapeutic breaks, carrying out careful and regular monitoring of the patient.
In any case, an abrupt interruption of treatment should be avoided by progressively reducing the dosage.
Patients with mild to moderate hepatic or renal insufficiency
The plasma concentration of the drug may be increased in mild or moderate renal or hepatic insufficiency. Therefore, in these patient groups, treatment should always be started with the lowest dosage: “5 mg + 325 mg” every 8 hours and with the utmost caution, regularly monitoring liver and / or renal function.
Elderly patients
In elderly patients (> 65 years of age), it is advisable to start treatment with the lowest dosage: “5 mg + 325 mg“; in addition, depending on the general state of the patient, the interval between two administrations, if deemed necessary, can be increased (from 6 hours to 8-12 hours).

Overdose

Paracetamol
Signs and symptoms : In case of overdose, paracetamol can cause hepatic cytolysis which can evolve towards massive and irreversible necrosis. Overdose can also manifest as renal tubular necrosis, hypoglycemic coma and thrombocytopenia.
In adults, liver toxicity occurred in acute poisoning with less than 10 grams, and mortality with less than 15 grams.
The early symptoms of a potential hepatotoxic overdose are: nausea, vomiting, diaphoresis and a feeling of general malaise. Clinical signs and laboratory values ​​demonstrating liver toxicity do not occur earlier than 48-72 hours after ingestion.
Treatment : In case of suspected acute paracetamol intoxication, the patient should be treated by gastric lavage or vomiting induced with syrup of ipecac. It is also advisable to request a dosage of paracetamol in the blood, but in any case not earlier than 4 hours after ingestion. Liver function should be evaluated initially and at 24 hour intervals.
The antidote, N-acetylcysteine, should be administered as soon as possible for best results, if possible within 16 hours of ingestion and in any case within 24 hours.
Oxycodone
Signs and symptoms : Symptoms are respiratory depression (decreased respiratory rate and / or tidal volume, Cheyne-Stokes breathing and cyanosis), extreme sleepiness which may progress to drowsiness or coma, musculoskeletal flaccidity, cold skin and sweaty, and sometimes bradycardia and hypotension. In the event of a severe overdose, apnea, cardiovascular collapse, cardiac arrest and death can occur.
Treatment : Particular attention must be paid to restoring adequate respiratory exchange by freeing the airways and instituting assisted or controlled ventilation.
In addition, an opioid antagonist, eg naloxone, specific antidote to respiratory depression induced by overdose or unusual hypersensitivity to opioids, should be given, and breathing should be controlled with adequate supportive measures.
The starting dose for adults is 0.4-2 mg of naloxone administered intravenously; Since oxycodone may have a longer duration of action than the antagonist, the patient should be kept under close surveillance and should receive repeated doses of naloxone in order to maintain adequate respiratory capacity.
The antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression.
If necessary, oxygen, intravenous solutions, vasopressors and other supportive measures should be used.
Gastric lavage should be used to remove unabsorbed drug.
size chest(in.) waist(in.) hips(in.)
XS 34-36 27-29 34.5-36.5
S 36-38 29-31 36.5-38.5
M 38-40 31-33 38.5-40.5
L 40-42 33-36 40.5-43.5
XL 42-45 36-40 43.5-47.5
XXL 45-48 40-44 47.5-51.5

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